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March 8, 2012

Speaker: Dr. Christopher Dockendorff, Broad Institute, Cambridge, Massachusetts

Title: Creative Synthetic chemistry approaches to probe and drug discovery

Abstract: Gene-silencing techniques have gained great utility in recent years for the study and modulation of biological systems, however the importance of small organic molecules for such purposes has not subsided. In particular, the creative use of synthetic organic chemistry continues unabated to provide valuable new tools for probing biology, as well as important lead compounds for drug discovery efforts. Select results from the fields of synthetic methodology development, diversity-oriented synthesis, and high-throughput screening will be presented in the context of discovering compounds with interesting and valuable bioactivities.